Abatacept-Orencia

Abatacept-Orencia

Generic Name :: Abatacept

Brand Name ::   Orencia

  

• Prescribed For

 This medication is a synthetic protein, prescribed for adult rheumatoid arthritis, and juvenile idiopathic arthritis. Abatacept  will only be prescribed if patients’s  arthritis is active and he/she have tried methotrexate and another disease modifying anti-rheumatic drug (DMARD) such as sulfasalazine or leflunomide.

• Preparation::

Powder for Injection: 250 mg. Prefilled Syringe: 125 mg/ml.

                                     

• Storage:  

This medicine should be refrigerated between 2-8 C (36-46 F). 

• Dosing

·         It is usually given in a doctor's office every 2 weeks for the first three doses and then every 4 weeks. It will take about 30 minutes for patients  to receive his/her  entire dose of abatacept.

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•  Side effects

 

·       

• ·         Nausea
• ·         Dizziness
• ·         Heartburn
•            Headache
• ·         Runny nose
• ·         Sore throat

•            Back pain

• ·         Arm or leg pain
• ·         Hives
• ·         Shortness of breath
• ·         Fever, chills, and other signs of infection
• ·         Dry cough that doesn't go away 
• ·         Skin rash
• ·         Itching
• ·         Swelling of the eyes, face, lips, tongue, or throat
• ·         Difficulty breathing or swallowing
•           Weight loss 
•           Requent urination or sudden need to urinate right away
• ·         Burning during urination
• ·         Cellulitis (red, hot, swollen area on the skin) 
•            Night sweats

•  About ABATACEPT / ORENCIA

 ORENCIA/ABATACEPT  is a soluble fusion protein. It consists of the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) linked to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1). This medicine  is produced by recombinant DNA technology in a mammalian cell expression system. It blocks the activity of T-cells, which causes swelling and joint damage in people with arthritis condition.

• More information 

• ·  FDA MedWatch

• ORENCIA® (abatacept) Official Site

• · Abatacept - 

 

 

Abarelix-Plenaxis

Abarelix-Plenaxis

• Generic Name :: Abarelix
• Brand Name ::  Plenaxis

•     Also known as :: 
• ·         CHEBI:337298,
• ·         Plenaxis depot,
• ·         PPI-149,
• ·         Plenaxis (TN),
• ·         CHEMBL1252
• ·         Abarelix [USAN],
• ·         Abarelix-Depot-M,
• ·         Abarelix (USAN/INN).

• Prescribed For

•  Used in the palliative treatment of advanced prostate cancer.
•  Reduces the amount of testosterone produced in the body
• This may also be used for purposes other than those listed in this medication guide.

 

•  Preparation::

                                     Vial contains + sodium chloride

• (A single-dose vial contains 113 mg of abarelix peptide in powder form, which must be mixed with .9% sodium chloride and injected intramuscularly.)

•  Storage:

Store the medication as directed by your Doctor

• Dosing

·         A dose of 100 mg of Plenaxis was administered via IM injection on Days 1, 15 and 29, then every 4 weeks. into the buttock/muscle

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•  Side effects

• ·         Hot flashes;
• ·         Pain
• ·         Sleep disturbances;
• ·         Breast enlargement or pain;
• ·         Diarrhea or constipation;
• ·         Swelling;
• ·         Nausea;
• ·         Constipation
• ·         Dizziness;
• ·         Headache;
• ·         Fatigue;
• ·         Changes with or difficulty urinating.
• ·         Myalgia
• ·         Flushing

•  About Abarelix

Abarelix directly suppresses luteinizing hormone (LH) and follicle stimulating hormone (FSH) secretion and thereby reducing the secretion of testosterone by the testes.It also inhibits gonadotropin and related androgen production by directly and competitively blocking GnRH receptors in the pituitary gland

• This Brand Name drug is no longer available in the US. (Generic versions may be available.)

• More information 

• ·        FDAMedwatch

• ·          The Plenaxis Web Site.

• ·         Abarelix